Epilepsy is a spectrum disorder characterized by recurring, unprovoked seizures. Although people often equate seizures with convulsions due to their obvious and dramatic nature; seizures are actually any abnormal, uncontrollable firing of neural networks within the brain. As a result, seizures can impact any function controlled by the brain.
While there are many types and causes of epilepsy, they all ultimately result from an imbalance of excitory and inhibitory brain-cell function. Restoring this balance can reduce or eliminate seizures, bringing epilepsy under control. While current medications manage some types of epilepsy effectively, other types are highly resistant to therapy (i.e. they are refractory). In addition, many patients feel lethargic and sleepy while taking their medication due to the sedative nature of these drugs.
NeuroCycle Therapeutics plans to evaluate its non-sedating compounds in several models of rare and severe forms of pediatric epilepsy that are refractory to treatment.