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Bar graph showing progress of three programs


Potential first-in-class, once-a-day, oral treatment of moderate-to-severe atopic dermatitis

  • NCT10004 effectively reduces itch within 30-60 minutes in preclinical models
  • NCT10004 significantly reduced rash by day 8 in repeat dose studies
  • Broad activity across all wide spectrum of itch models
  • Expected to enter clinical trials in 4Q2019


An advanced lead being evaluated as a next generation treatment of Dravet Syndrome.

NCE Program

Lead optimization program powered by new GABAA receptor structural data obtained by X-ray crystallography and cryo-electron microscopy, and cutting edge in silico models.