Itch is a caused by a number of different medical conditions including contact dermatitis, atopic dermatitis, psoriasis, kidney dialysis, and diabetes. Some forms of acute itch can be treated with antihistamines or corticosteroids. However, the majority of patients with severe and/or chronic itch do not receive adequate relief of their symptoms with current therapies.

Our clinical candidate for itch, NCT-10004, is being developed for treatment of atopic dermatitis. Atopic dermatitis (AD) is an inflammatory skin condition characterized by intense itching and rash. AD afflicts 15-30% of children and 2-10% of adults. Family stress related to caring for children with moderate or severe AD (from sleep deprivation, loss of employment, time-consuming treatment, and financial costs) may rival those related to caring for children with type 1 diabetes.